(20% Florfenicol Powder)

Perfectly solve the problem of water dissolution, high efficiency, fast absorption, high effective blood drug concentration and safety, no chloramphenicol, thiamphenicol residues of pure levoflorfenicol raw materials

1. Problems with common preparations

1.1 Very slight dissolution and slow dissolution in water can not meet the requirements of clinical medication, slow absorption and low bioavailability.

1.2 Drug resistance is prominent and the clinical effect is not satisfactory.

1.3 Residues of chloramphenicol and thiamphenicol are prone to occur.

2. Fukexin's characteristics

2.1 Raw material and auxiliary materials

Fukexin used levoflorfenicol as raw material after strict purification process, and its impurities were controlled below 0.2%.

With the addition of imported auxiliary materials, the application of American preparation technology, scientific verification and strict quality control, the accuracy of Fukexin is consistent.

Ordinary florfenicol has the same left-handed and right-handed in the original molecule. Only left-handed is effective. Right-handed is completely useless or even toxic. The absorption rate of left-handed florfenicol is 2-3 times higher than that of ordinary florfenicol, and its activity is 8 times higher than that of right-handed florfenicol.

2.2 Fukexin thoroughly resolved three major problems existing in common florfenicol preparations

1) Perfect Solution of Water Dissolution Problem

Florfenicol itself is almost insoluble in water, and domestic preparations can greatly destroy the active ingredients and reduce the curative effect by adding acid, alkali and other cosolvents. Fukexin uses American pharmaceutical technology to make flufenicol fully soluble in water and uniformly distributed, and can ensure 99% non-degradation in water for 12 hours.

Validation of solubility: accurately weigh Fukexin, imported products and domestic products of the same kind 0.3 grams, add 100 ml water (equivalent to 600 grams of pure florfenicol per ton of water) and stir for 30 minutes. The dissolution of each product is shown in Figure 1.


Fig. 1 Field dissolution test of Fukexin and similar products at home and abroad

Note: A-Fukexin; B-Imported similar products; C-domestic similar products

Conclusion: Compared with similar products, Fukexin dissolves in water more quickly and completely, which is very beneficial to group drinking water.

2) Efficient: fast absorption, high blood concentration

Fukexin uses the process-purified L-florfenicol raw materials and imported excipients, and uses the American pharmaceutical technology to achieve a peak plasma concentration of 1 hour after administration, which is 1.8 times higher than the domestic preparations, so that the florfenicol can be bactericidal action.

Bioequivalence validation: 30-day-old broilers were given the same dose of Fukexin, imported products and domestic products. Blood samples were collected at different time points after administration, and the plasma drug concentration was determined by HPLC. Blood drug concentrations at different time points are shown in Figure 2.


Fig 2 The pharmacokinetic curve of Fukexin and similar products at home and abroad in broilers

Conclusion: The pharmacokinetic curve of Fukexin and imported powder is basically the same. The peak concentration of blood is reached in 1 hour, and the peak concentration is about 1.8 times that of domestic powder.

3) Safe, no residue

Fukexin selected the raw material of florfenicol and purified it strictly, which fundamentally solved the problem of residual chloramphenicol and thiamphenicol that customers worried about.

Fukexin residue detection test: Fukxin was given to chickens through water at recommended dosage for 3 days. Chest muscle, liver and kidney were taken from chickens 1, 3, 5 and 7 days after drug withdrawal, and the contents of florfenicol and chloramphenicol were detected respectively. The results are shown in Table 1.

Table 1 Results of the residue test of Fukexin

Drug withdrawal time (days)

Residual concentration of Florfenicol mg·kg-1

Residual concentration of chloramphenicol mg·kg-1




































Note: The detection limit is 10ng•g-1, ND means no detection


The residues of florfenicol in breast muscle were less than 50 g/kg on the 5th day after discontinuation of Fukexin in poultry for 3 consecutive days. No residues of florfenicol were detected in liver and kidney. No residues of chloramphenicol were detected in breast muscle, liver and kidney on the 1st, 3rd, 5th and 7th day after application of Fukexin.

3. Fukexin's application

Table 2 Fukexin usage program

Applicable animal

Usage and dosage

Compatible drugs

Mainly controlled disease


Water medication: Every 500g of this product dissolves in 2000 kg of water. For 3-5 days

Neomycin Sulfate, Doxycycline Hydrochloride, Colistin Sulfate, etc.

Escherichia coli, white diarrhea and typhoid fever


Escherichia coli disease and infectious serositis in ducks

Withdrawal time: Pig 20 days; chicken 5 days.

Validity: 2 years

Content: 20%

Packaging and storage: 500g/bottle *12 bottles/box. Keep in a sealed, dry place

Function: It is used to prevent infection caused by sensitive bacteria of pigs and chickens.