Strong tissue penetration, high concentration can be achieved in blood, tissues and airbags within 2 hours of medication.

ü Extensive spectrum, rapid killing of various pathogenic microorganisms.

ü High safety, non-toxic for long-term use over 25 times recommended dose.

1. Pharmacological effects of Enrofloxacin

1.1 Enrofloxacin is a broad-spectrum bactericide of fluoroquinolones. It has good effects on E. coli, Salmonella, Klebsiella, Brucella, Pasteurella, Actinobacillus pleuropneumoniae, Erysipelas, Proteus, Serratia mucinosa, Corynebacterium pyogenes, Porter septicum, Staphylococcus aureus, Mycoplasma and Chlamydia, but weak effects on Pseudomonas aeruginosa and Streptococcus, and weak effects on anaerobic bacteria. Posterior antimicrobial effect on sensitive bacteria.

1.2 The antimicrobial mechanism of this product is to inhibit bacterial DNA cyclase, interfere with bacterial DNA replication, transcription, repair and recombination, bacteria can not grow and multiply normally and die.

2. Pharmacokinetics of Enrofloxacin

2.1 Most animals take this product orally and absorb it well. The bioavailability of chicken oral administration is 62.2%~84%. It is widely distributed in poultry and can enter tissues and body fluids (including skeleton). Except cerebrospinal fluid, the drug concentration in almost all tissues is higher than that in plasma. The liver metabolism is mainly the production of ciprofloxacin by removing the ethyl group of 7-piperazine ring, followed by oxidation and glucuronic acid binding.

2.2 It is mainly excreted through the kidney (secreted by the renal tubule and filtered by the glomerulus), and 15%-50% of it is excreted from the urine in its original form. The elimination half-life of chicken oral administration is 9.1-14.2 hours.

3. Huanuoxin’s characteristics:

3.1 Imitate Byroxin from Bayer Company, Germany, with unique preparation technology.

3.2 Strong tissue penetration, high concentration can be achieved in blood and various tissues, especially in airbags, within 2 hours of medication.

3.3 It can be transported to the infected site with macrophages and targeted to the diseased tissues.

3.4 High bioavailability. Huanuoxin bioavailability is twice that of ordinary enrofloxacin;

3.5 Extensive spectrum, rapid killing of mycoplasma, Escherichia coli, Salmonella and other pathogenic microorganisms;

3.6 It does not affect the establishment of immunity.

3.7 It does not affect the laying rate, fertilization rate and hatching rate, and has no teratogenic effect.

3.8 High safety, over 25 times the recommended dose of long-term use of non-toxic;

3.9 The unique mechanism of action and the concentration of blood and tissue are far greater than the concentration of anti-mutation (MPC), which makes it difficult to produce drug resistance.

3.10 It has high stability. The concentration of 20-200 PPM in water with pH value of 6.5-7.5 and 50℃ is maintained for at least 48 hours.

4. Compatibility of Huanuoxin

Huanuoxin + Anlisu series, 1+1>2 medication selection

4.1 Reduce the risk of drug resistance caused by stress.

4.2 Intestinal tract is healthier and its efficacy is easier to exert.

4.3 Strengthen the resistance of chicken flocks and accelerate the recovery after illness.

Huanuoxin and Anlisu combination can be used for the prevention and treatment of almost all common diseases. These diseases are Mycoplasma disease (chronic respiratory disease), Escherichia coli (E. coli perihepatitis, peritonitis, etc.), Salmonellosis (white diarrhea, typhoid fever), Infectious rhinitis, Avian Pasteurellosis (fowl cholera), Staphylococcosis and other bacterial diseases.

5. Drug regimen of combination of Huanuoxin and Anlisu

5.1 Broiler 3-week-old Wall Program

In commercial broiler production, once CRD or CCRD occurs and antibiotics are used for treatment, the loss has occurred, the condition is often complex, and the effect cannot be guaranteed. Early in the infection, that is, chicks start feeding and at 3 weeks of age are planned to use Huanuoxin and Anlisu combination to minimize the infection pressure of bacteria and mycoplasma, and help broilers to successfully pass through the window of respiratory diseases.

Table 1 Medicinal Procedures for Broilers

5.2 Four Key Points Control Scheme for Chicken Breeding

For breeding chickens, the growth cycle is longer, so it is very important to select the key points to prevent the infection of bacteria and mycoplasma in order to help the chickens pass through the susceptible stage of respiratory diseases smoothly. Huanuoxin and Anlisu Combination-Four Key Point Control Strategies: According to the pathogenesis of respiratory diseases in breeding chickens, effective prevention of respiratory diseases in the early stage of brooding and rearing, and purification of chickens before laying are carried out, so as to maximize the health level of chickens.

Table 2 Drug regimen for laying hens and breeding hens

6. Adverse reactions

6.1 Degeneration of cartilage in young animals, affecting bone development and causing lameness and pain.

6.2 The reaction of the digestive system is loss of appetite, diarrhea, etc.

7. Notes

7.1 Avoid mixing with acidic drugs to prevent failure.

7.2 For livestock and poultry that have used chloramphenicol first, it takes 48 hours to use this medicine to avoid reduction.

7.3 Enrofloxacin cannot be administered with chloramphenicol, tetracycline, macrolide antibiotics (the above antagonistic effects), theophylline and steroids.

7.4 Drugs containing divalent and trivalent cations (Ca2+, Mg2+, Al3+, Fe3+), such as antacids, aluminum sulfate and nutritional supplements, can bind to enrofloxacin to form a chelate, thereby inhibiting the absorption of oral enrofloxacin.

ü Withdrawal period: poultry 8 days.

ü Specification: 10%

ü Packaging: 250ml/bottle *12 bottles/box

ü Storage: Shading, sealed preservation

ü Approval No.: Veterinary medicine 150961298

ü Validity Period: 2 years.