Commodity name: Xinzhilin

English name: Tiamulin Fumarate Soluble Powder

General name: 45% Tiamulin fumarate soluble powder

Packaging Specification: 500g/bottle ×12 bottles/box

Content: 45%

Validity: 2 years

Usage: water medication: add 125-250 grams of Xinzhilin per ton of water for 4 days

Manufacture: Shandong Huachen Pharmaceutical Co.Ltd.

Tiamulin Fumarate: Efficient Eradication of Mycoplasma

1. Usage Characteristics of Tiamulin

Tiamulin is a diterpenoid antibiotic for animals. It is mainly used to prevent and treat respiratory diseases of livestock and poultry and promote animal growth. It has strong antimicrobial activity and can effectively kill Mycoplasma gallisepticum and Mycoplasma synovialis.

2. Characteristics of Xinzhilin

2.1 Efficient Purification of Mycoplasma

The minimum inhibitory concentration of tiamulin fumarate against different Mycoplasma species was determined and compared with levofloxacin, tylosin tartrate, lincomycin hydrochloride and doxycycline hydrochloride. The results showed that tiamulin fumarate had high antimicrobial activity against various mycoplasmas and could inhibit the growth of Mycoplasma at very low concentration (Table 1).

Table 1 Minimum inhibitory concentration (MIC) of tiamulin fumarate for different Mycoplasma species

A large number of studies have shown that Mycoplasma gallisepticum is not resistant to tiamulin. Mycoplasma gallisepticum strains isolated from several domestic farming areas were sensitive to tiamulin (MIC value remained at a very low level), but resistant to tylosin, doxycycline hydrochloride, ofloxacin and lincomycin. Therefore, tiamulin is the preferred drug for the prevention and treatment of respiratory diseases caused by Mycoplasma gallisepticum.

2.2 High blood drug concentration:

Through the preparation process, the absorption and maintenance time of blood drug concentration were improved. The results showed that the absorption and utilization of Xinzhilin in poultry were the same as that of imported similar preparations, which were significantly superior to those of domestic common preparations. See Figure 1.

Fig. 1 Drug-time curves of Xinzhilin and similar products at home and abroad in Broilers

2.3 The dissolution rate is fast:

Dissolution rate is the dissolution rate and degree of active ingredients in solid pharmaceutical preparations in a specific dissolving medium. It directly affects the absorption rate and degree of drugs, and is closely related to the efficacy of drugs. The dissolution rate of Xinzhilin was faster than that of imported products to ensure drug absorption.

Figure 2 Comparison of dissolution rates of Xinzhilin and imported powders

2.4 Good stability in water:Broiler chickens are mainly administered by drinking water. The drug can be quickly dissolved in a relatively short time and the active ingredients can not be lost in water for 24 hours through the preparation process. The stability of Xinzhilin in water is identical with that of imported products.

Fig. 3 Room temperature stability test of tap water solution of tiamulin fumarate soluble powder

2.5 Promote growth and improve efficiency:

The results showed that the laying rate, fertilization rate, hatching rate and healthy chick rate of laying hens were 3.91%, 2.26%, 2.23% and 2.22% higher than those of the control group after using Xinzhilin.

The survival rate and weight gain rate of broilers were 2.33% and 2.59% higher than those of the control group.

3. Matters needing attention

3.1 When using Xinzhilin, do not use it with salinomycin, methylsalinomycin and monensin, or it will lead to chicken poisoning and death. But it can be safely used with other chemical anti-coccidial drugs.

3.2 Chicken flocks are infected with severe respiratory diseases caused by mycoplasma. The dosage can be increased to 500 grams per 2000 kg of water. It can be used separately with Anlisu (10% amoxicillin soluble powder) or Liduomeixin (10% doxycycline hydrochloride soluble powder), which can effectively prevent the secondary infection of other bacteria.

3.3 The use of unqualified products will only rapidly increase the resistance of mycoplasma, leading to more complex diseases in chickens; the drug concentration of Mycoplasma treatment is increasing, and the cost is increasing.

4. Application of Xinzhilin in Broiler Chicken

4.1 Chicken chronic respiratory diseases caused by Mycoplasma gallisepticum and Mixed infection of E. coli are one of the most serious diseases affecting the performance of commercial broilers, causing serious economic losses in production.

4.2 Because of the poor breeding environment and serious Mycoplasma pollution in China, drug control is one of the main measures to improve the production performance of commercial broilers to control the occurrence of chronic respiratory diseases and colibacillosis. Tiamulin fumarate is the preferred drug to control Mycoplasma in broiler chickens at present. The following control schemes can be used for reference.

Table 2. Usage and dosage of Xinzhilin

l The four-stage medication recommended by this scheme can be used flexibly according to the actual situation on the spot.

l The above recommended doses are all drinking water doses, and the feed medication dosage should be doubled.

l It is suggested that the total drug dosage should be consumed twice within 8 hours (4 hours each time, once in the morning and once in the afternoon) and that the total water consumption should be calculated by twice the feed amount throughout the day. It is suggested that the time of taking medicine should be doubled after 20 days of age in order to avoid affecting food intake.

5. Application Scheme of Xinzhilin on Laying Hens

5.1 Add 125-250g of Xinzhilin (in terms of active ingredients) per ton of water for 3 days, and then add 250-330g of Fukexin per ton of water for 4 days.

5.2 Each ton of water was added with Xinzhilin (in terms of active ingredients) 125-250g + 10% doxycycline hydrochloride soluble powder 1000 g for 3 days.

Table 3 Effect of Xinzhilin on laying hens

6. Conclusion

Xinzhilin uses imported raw materials and excipients through the first-class production process to improve the drug absorption and blood drug concentration maintenance time. Compared with imported product, Xinzhilin has the same stability, faster dissolution rate, and relatively better assurance of drug absorption.

ü Efficient eradication of mycoplasma, not easy to produce drug resistance

ü No loss of 24-hour active ingredients in water

Good palatability, growth promotion and economic benefits