Tiamulin is a semi-synthetic semi-fermented pleuromutilin (biguanide) antibiotic, which is a white or yellow crystalline powder. Its fumarate is soluble in water and chemically stable. It is an animal-specific antibiotic.

Tiamulin has a strong pungent odor that can affect the animal's feed intake.

【Function and use】

It is a bacteriostatic antibiotic, but the high concentration also has a bactericidal effect on sensitive bacteria. The mechanism of antibacterial action is to inhibit bacterial protein synthesis by binding to the bacterial ribosome 50s subunit.

This product has strong antibacterial effect on various mycoplasma, Gram-positive bacteria (especially staphylococcus aureus, streptococcus), treponema, etc., and has stronger effect on mycoplasma than tylosin, but on enterobacteria, the effect is poor. It is mainly used for the prevention and treatment of asthma caused by mycoplasma hyopneumoniae, swine dysentery caused by treponema, and ileitis caused by lawsonia intracellularis. It is also used for actinobacillus pleuropneumonia pleuropneumonia.

Table 1 Minimum inhibitory concentration (MIC) of tiamulin, telavancin and tylosin against T. hyodysenteriae

【Pharmacokinetics】

This product is easy to absorb in pigs. The single dose can be absorbed by about 85%, and the peak concentration of blood is reached in 2-4h. It is widely distributed in the body and has the highest drug concentration in the lungs. Tiamulin is metabolized into 20 metabolites in the body, some with antibacterial activity. About 30% of the metabolites are excreted in the urine and the rest are excreted from the feces. No adverse effects on immunity, growth and development during medication.

The resistance of bacteria (mycoplasma, Gram-positive bacteria, etc.) to tiamulin is slow. Low cross-resistance with tylosin, erythromycin, etc.

【Indication】

This product is mainly used for the prevention and treatment of mycoplasma pneumoniae or respiratory disease syndrome (PRDC), mycoplasma hyorhinis, mycoplasma synoviae infection, actinobacillus pleuropneumonia, swine dysentery caused by treponema, and ileitis caused by Lawsonia intracellularis.

Low doses can promote growth and increase feed conversion.

【Medicine interactions】

Tiamulin has synergistic effects with tetracyclines, amoxicillin and the like. For example, the combination of tiamulin and chlortetracycline can produce 2 to 8 times synergistic effect on most pathogenic bacteria, and some can even reach 250 times (see Table2). Synergies are also manifested in the expansion of the antibacterial spectrum. Although in theory, tiamulin and florfenicol are incompatible, they are often used in production.

Combination of tiamulin with ionophore antibiotics such as monensin, salinomycin, methyl salinomycin, and lasalocid can increase the toxicity of the latter, causing death or other serious side effects.

Table 2 Antibacterial activity of tiamulin combined with chlortetracycline (Burch DGS, etc.)

【Comparison of Miaokemei and similar preparations】

Table 3 Comparison of Miaokemei and similar preparations

【Usage and dosage】

Usage: Feed administration

Dosage: 15mg/kg body weight

Pig, mixed feed: 40~100g/ton of material, used for 5-10 days.

【Miaokemei clinical application】

1. Prevention of post-weaning multisystemic wasting syndrome (PMWS)）

Each ton of feed adds Miaokemei 125g + 50% Liduomeixinore 160g + 20% Fukexin300g, used for 7 to 10 days after weaning.

2. Prevent respiratory diseases in growing and finishing pigs

Each ton of feed is supplemented with Miaokemei125g+50% Liduomeixin160g +20% Fukexin 300g, and transferred to the growing and finishing pig house (or around 12 weeks old) for 7~10 days.

3. The gilt breeding stage, or before breeding

Each ton of feed adds Miaokemei 125g+50% Liduomeixin 160g+20% Fukexin 300g, used for 7 to 10 days. Note that if you are in the restricted feeding phase, you need to increase the amount of addition.

4. Prevention of sows, mastitis, postpartum lactation syndrome

Each ton of feed is added with Miaokemei 125g+50% Liduomeixin 200g+30% Anlisu 400g, 10 days before and after farrowing.

5. Treatment of ileitis, swine dysentery, etc.

Each ton of feed adds Miaokemei 125g+50% Liduomeixin 200g, used for 7 days, and then add Miaokemei 80g+50%Liduomeixin120g, for another 14 days.

Table 4 Miaokemei Usage

【Miaokemei Features】

1. Good palatability: unique coating process, effectively masking the strong pungent odor of tiamulin without affecting feed intake.

2. Good fluidity: The coated particles are evenly sized and therefore easier to mix in the feed.

3. Good stability: High temperature granulation is not easy to break.

【Precautions】

1. When the ambient temperature exceeds 40℃, the storage period of the medicated feed shall not exceed 7 days.

2. It is strictly forbidden to add in the feed containing monensin, salinomycin, methyl salinomycin and lasalocidin.

3. Pay attention to personal protection and avoid contact with eyes.

【Withdrawal time】

Pig, 7 days

【Storage】

Sealed, protected from light, stored in a ventilated, cool, dry, free of pollutants, no toxic and hazardous substances.

【Validity period】

2 years

【Packing specification】

Content: 100g: 80g

Packing: 500g / can, 12 cans / box